Projects

The Metabolomics Innovation Centre (TMIC) is a nationally-funded core facility that has a unique combination of infrastructure and personnel to perform a wide range of cutting-edge metabolomic studies for clinical trials research, biomedical studies, bioproducts studies, nutrient profiling and environmental testing.

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The Prion Structure, Function & Dynamics Project is a collaboration between researchers from the University of Alberta, the University of Toronto and the University of British Columbia. Our goal is study the structure, function and dynamics of the Prion protein.

We apply tools of structural biology, biophysics, biochemistry, molecular biology and bio-computing to an understanding of the mechanisms of BSE, TSE and other diseases of protein misfolding.

Misfolded prions cause a variety of fatal neurodegenerative diseases in both animals and humans.

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Metabolomics is a newborn cousin to genomics and proteomics. Specifically, metabolomics involves the rapid, high throughput characterization of the small molecule metabolites found in an organism. Since the metabolome is closely tied to the genotype of an organism, its physiology and its environment (what the organism eats or breathes), metabolomics offers a unique opportunity to look at genotype-phenotype as well as genotype-envirotype relationships. Metabolomics is increasingly being used in a variety of health applications including pharmacology, pre-clinical drug trials, toxicology, transplant monitoring, newborn screening and clinical chemistry. However, a key limitation to metabolomics is the fact that the human metabolome is not at all well characterized. This project aims to address that limitation by building the largest resource of metabolomics data in the world.

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The Genome Canada Help Desk was a Genome Canada funded project that ran from 2003-2011. The HelpDesk offered bioinformatics services, research, tools, and databases to the scientific community. Databases such as DrugBank were created with Help Desk funding. The Help Desk software repository is available for free, without restriction on our bitbucket site.

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